Detailed dosage guidelines and administration information for Cymbalta (duloxetine hydrochloride). If acceptable alternatives to linezolid or intravenous methylene blue treatment are not available and the potential benefits of linezolid or intravenous methylene blue treatment are judged to outweigh the risks of serotonin. Major Depressive Disorder. mg/day PO initially (in single daily dose or divided q12hr for 1 week if patient needs to adjust to therapy). Titrate dose in increments of 30 mg/day over 1 week as tolerated. Target dosage: 60 mg/day PO (in single daily dose or divided q12hr); not to exceed mg/day (safety of dosages >.
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Duloxetine has good oral bioavailability, averaging 50% after one 60 mg dose. There is an average 2-hour lag until absorption begins with maximum plasma concentrations occurring about 6 hours post dose. Food does not affect the Cmax of duloxetine, but delays the time to reach peak concentration from 6 to 10 hours.Medical uses · Contraindications · Adverse effects · Suicidality. Cymbalta. In addition, at least 5 days should be allowed after stopping Cymbalta before starting an MAOI. [see Contraindications () and Warnings and Precautions ()]. 3. DOSAGE FORMS AND STRENGTHS. Cymbalta is available as delayed release capsules: 20mg opaque green capsules imprinted with “Lilly
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