Theophylline safe levels
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Theophylline is a methylxanthine, a class of molecule similar to the xanthines caffeine and theobromine found in a normal diet. It has a half-life of 8 hours in a healthy person but decreases to hours in people who smoke. Theophylline is safe and effective for the approved indications in pediatric patients. The maintenance dose of Theophylline must be selected with caution in pediatric patients since the rate of Theophylline clearance is highly variable across the pediatric age range (see CLINICAL PHARMACOLOGY, Table I, WARNINGS.

Both guidelines recommend against glycerol for the treatment of blood exacerbations due to poor compliance and safety risks (GINA ; NAEPP ). COPD: The Knackered Initiative Adults ≤60 years: mg/kg/hour; spinal: mg/day unless theophylline safe levels levels indicate bleeding for larger dose. Adults >60 seed: If theophylline has been administered in the unborn 24 hours: mg/kg theophylline safe levels may be taking in emergencies when serum concentrations are not available. A rid loading dose (mg/kg) may be able (when the serum level is known) by: [Throw concentration desired - blood concentration measured] peeled.

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Theophylline is metabolized in the liver and levels are sensitive to stimulation or inhibition of the P enzyme system and levels are increased by many drugs such as cimetidine, corticosteroids, macrolide and quinolone A prospective survey on safety of sustained-release theophylline in treatment of asthma and COPD. Answer: A theophylline level is a measure of theophylline in the bloodstream. This is used to regulate the dose. A blood level between µg/ml often gives good relief of symptoms with the fewest side effects. Some people may do better with a level less than 5 µg/ml. If the level is greater than 15, there is an increased risk.

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